Article: article from journal or magazin.
A whole-genome association study of major determinants for host control of HIV-1
Journal Article Multicenter Study Research Support, Non-U.S. Gov't --- Old month value: Aug 17
Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen (HLA)-B*5701, whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.
Cohort Studies DNA-Binding Proteins/genetics Disease Progression Female Genes, MHC Class I *Genome, Human HIV Infections/*genetics/immunology/therapy/*virology HIV-1/*physiology HLA-B Antigens/*genetics HLA-C Antigens/*genetics Haplotypes Humans Immediate-Early Proteins/genetics Major Histocompatibility Complex/*genetics Male Polymorphism, Single Nucleotide Regression Analysis Viral Load
Web of science
Last modification date