The micro-architecture estimation by TBS discriminate women with and without osteoporotic fracture independently of age, BMI and BMD: The Osteo-Mobile Vaud cohort study.
Details
Serval ID
serval:BIB_FED6F665AAF2
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
The micro-architecture estimation by TBS discriminate women with and without osteoporotic fracture independently of age, BMI and BMD: The Osteo-Mobile Vaud cohort study.
Title of the conference
Interdisziplinärer Fachkongress OSTEOLOGIE des Dachverbandes Osteologie (DVO)
Address
Basel, Schweiz, 29.-31. März 2012
ISBN
1019-1291
Publication state
Published
Issued date
2012
Volume
21
Series
Osteologie
Pages
A23-A24
Language
english
Abstract
Introduction: « Osteo-Mobile Vaud » is a mobile osteoporosis (OP) screening
program. The women > 60 years living in the region Vaud will be offered OP
screening with new equipment installed in a bus. The main goal is to evaluate
the fracture risk with the combination of clinical risk factors (CRF) and informations
extracted by a single DXA: bone mineral density (BMD), vertebral
fracture assessment (VFA), and micro-architecture (MA) evaluation. MA is yet
evaluable in daily practice by the Trabecular Bone Score (TBS) measure. TBS
is a novel grey-level texture measurement reflecting bone MA based on the use
of experimental variograms of 2D projection images. TBS is very simple to obtain,
by reanalyzing a lumbar DXA-scan. TBS has proven to have diagnosis
and prognosis value, partially independent of CRF and BMD. A 55-years follow-
up is planned.
Method: The Osteo-Mobile Vaud cohort (1500 women, > 60 years, living in
the region Vaud) started in July 2010. CRF for OP, lumbar spine and hip BMD,
VFA by DXA and MA evaluation by TBS are recorded. Preliminary results are
reported.
Results: In July 31th, we evaluated 510 women: mean age 67 years, BMI 26
kg/m². 72 women had one or more fragility fractures, 39 had vertebral fracture
(VFx) grade 2/3. TBS decreases with age (-0.005 / year, p<0.001), and with
BMI (-0.011 per kg/m², p<0.001). Correlation between BMD and site matched
TBS is low (r=0.4, p<0.001). For the lowest T-score BMD, odds ratio (OR, 95%
CI) for VFx grade 2/3 and clinical OP Fx are 1.8 (1.1-2.9) and 2.3 (1.5-3.4). For
TBS, age-, BMI- and BMD adjusted ORs (per SD decrease) for VFx grade 2/3
and clinical OP Fx are 1.9 (1.2-3.0) and 1.8 (1.2-2.7). The TBS added value was
independent of lumbar spine BMD or the lowest T-score (femoral neck, total
hip or lumbar spine).
Conclusion: As in the already published studies, these preliminary results
confirm the partial independence between BMD and TBS. More importantly,
a combination of TBS and BMD may increase significantly the identification
of women with prevalent OP Fx. For the first time we are able to have complementary
information about fracture (VFA), density (BMD), and micro-architecture
(TBS) from a simple, low ionizing radiation and cheap device: DXA.
The value of such informations in a screening program will be evaluated.
program. The women > 60 years living in the region Vaud will be offered OP
screening with new equipment installed in a bus. The main goal is to evaluate
the fracture risk with the combination of clinical risk factors (CRF) and informations
extracted by a single DXA: bone mineral density (BMD), vertebral
fracture assessment (VFA), and micro-architecture (MA) evaluation. MA is yet
evaluable in daily practice by the Trabecular Bone Score (TBS) measure. TBS
is a novel grey-level texture measurement reflecting bone MA based on the use
of experimental variograms of 2D projection images. TBS is very simple to obtain,
by reanalyzing a lumbar DXA-scan. TBS has proven to have diagnosis
and prognosis value, partially independent of CRF and BMD. A 55-years follow-
up is planned.
Method: The Osteo-Mobile Vaud cohort (1500 women, > 60 years, living in
the region Vaud) started in July 2010. CRF for OP, lumbar spine and hip BMD,
VFA by DXA and MA evaluation by TBS are recorded. Preliminary results are
reported.
Results: In July 31th, we evaluated 510 women: mean age 67 years, BMI 26
kg/m². 72 women had one or more fragility fractures, 39 had vertebral fracture
(VFx) grade 2/3. TBS decreases with age (-0.005 / year, p<0.001), and with
BMI (-0.011 per kg/m², p<0.001). Correlation between BMD and site matched
TBS is low (r=0.4, p<0.001). For the lowest T-score BMD, odds ratio (OR, 95%
CI) for VFx grade 2/3 and clinical OP Fx are 1.8 (1.1-2.9) and 2.3 (1.5-3.4). For
TBS, age-, BMI- and BMD adjusted ORs (per SD decrease) for VFx grade 2/3
and clinical OP Fx are 1.9 (1.2-3.0) and 1.8 (1.2-2.7). The TBS added value was
independent of lumbar spine BMD or the lowest T-score (femoral neck, total
hip or lumbar spine).
Conclusion: As in the already published studies, these preliminary results
confirm the partial independence between BMD and TBS. More importantly,
a combination of TBS and BMD may increase significantly the identification
of women with prevalent OP Fx. For the first time we are able to have complementary
information about fracture (VFA), density (BMD), and micro-architecture
(TBS) from a simple, low ionizing radiation and cheap device: DXA.
The value of such informations in a screening program will be evaluated.
Create date
24/01/2013 12:08
Last modification date
20/08/2019 17:29
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