Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.

Details

Serval ID
serval:BIB_FE7ACE5982F5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF.
Journal
Nature cell biology
Author(s)
Quail D.F., Olson O.C., Bhardwaj P., Walsh L.A., Akkari L., Quick M.L., Chen I.C., Wendel N., Ben-Chetrit N., Walker J., Holt P.R., Dannenberg A.J., Joyce J.A.
ISSN
1476-4679 (Electronic)
ISSN-L
1465-7392
Publication state
Published
Issued date
08/2017
Peer-reviewed
Oui
Volume
19
Number
8
Pages
974-987
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonstrate that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour. The increase in lung neutrophils translates to increased breast cancer metastasis to this site, in a GM-CSF- and IL5-dependent manner. Importantly, weight loss is sufficient to reverse this effect, and reduce serum levels of GM-CSF and IL5 in both mouse models and humans. Our data indicate that special consideration of the obese patient population is critical for effective management of cancer progression.

Pubmed
Web of science
Create date
28/08/2017 10:04
Last modification date
20/08/2019 16:29
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