Understanding what makes a good versus a bad vaccine
Details
Serval ID
serval:BIB_FE51441F1B0A
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Understanding what makes a good versus a bad vaccine
Journal
European Journal of Immunology
ISSN
0014-2980 (Print)
Publication state
Published
Issued date
09/2005
Volume
35
Number
9
Pages
2528-31
Notes
Comment
Journal Article --- Old month value: Sep
Journal Article --- Old month value: Sep
Abstract
The majority of the HIV vaccines under development are aimed at stimulating T cell responses. Therefore, it is critical to delineate the factors regulating the generation of the T cell responses and to develop strategies maximizing vaccine-induced T cell responses. The identification of these factors and the delineation of the kinetics of the generation of vaccine-induced immune responses have been hard to investigate, due to the limited number of precursor naive antigen-specific T cells. To overcome these obstacles, Estcourt and collaborators have developed an elegant strategy that consists of an in vivo mouse model employing transfer of naive CFSE-labeled TCR-transgenic T lymphocytes into syngeneic nontransgenic recipients prior to vaccination. Using this model, the authors demonstrate that the dose, the route of administration and the type of vaccine determine the magnitude, the dissemination and the kinetics of vaccine-induced T cell responses. Furthermore, the mouse model of Estcourt and collaborators may represent the basis for the development of powerful in vivo experimental strategies to evaluate vaccine candidates.
Keywords
AIDS Vaccines/administration & dosage/*immunology/standards
Animals
CD8-Positive T-Lymphocytes/immunology
Genetic Vectors/immunology
HIV Infections/*immunology/prevention & control
HIV-1/*immunology
Humans
Mice
Vaccination/*methods/standards
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 15:00
Last modification date
20/08/2019 16:28