Laboratory confirmed polymethyl-methacrylate (Palacos)-hypersensitivity after cranioplasty.

Details

Serval ID
serval:BIB_FE0D88DE1773
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Laboratory confirmed polymethyl-methacrylate (Palacos)-hypersensitivity after cranioplasty.
Journal
Clinical neurology and neurosurgery
Author(s)
Gautschi O.P., Schlett C.L., Fournier J.Y., Cadosch D.
ISSN
1872-6968 (Electronic)
ISSN-L
0303-8467
Publication state
Published
Issued date
12/2010
Peer-reviewed
Oui
Volume
112
Number
10
Pages
915-916
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Abstract
Polymethyl-methacrylate (PMMA) as part of bone cement is a widely used material in the context of orthopaedic implants and also in cranioplasty. Although PMMA is characterised by excellent biocompatibility with low intrinsic toxicity and inflammatory activation, a minor portion of patients develop allergic reactions. We present the case of a 39-year-old woman with an increasing headache and a corresponding erythema over the parieto-occipital cranioplasty, which was performed 42 days prior using a PMMA compound. A patch test specific for bone cement components confirmed the diagnosis of a PMMA delayed-type hypersensitivity reaction. The prevalence of allergic reactions to bone cement components are known to vary from between 0.6% and 1.6%, however no adequate, pre-interventional diagnostic tool is currently available. Therefore, physicians are required to consider this differential diagnosis even after an extremely delayed onset of symptoms. This case describes the first ever-reported case in the literature of hypersensitivity to bone cement cranioplasty.
Keywords
Adult, Anaphylaxis/etiology, Bone Cements/adverse effects, Craniotomy, Drug Hypersensitivity/diagnosis, Drug Hypersensitivity/surgery, Female, Humans, Hypersensitivity, Delayed/diagnosis, Leukocyte Count, Polymethyl Methacrylate/adverse effects, Prostheses and Implants
Pubmed
Web of science
Create date
25/03/2024 19:38
Last modification date
26/03/2024 7:11
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