Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?

Details

Serval ID
serval:BIB_FE07A662A267
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?
Journal
Future oncology
Author(s)
Weller M., Wick W., Hegi M.E., Stupp R., Tabatabai G.
ISSN
1744-8301 (Electronic)
ISSN-L
1479-6694
Publication state
Published
Issued date
09/2010
Peer-reviewed
Oui
Volume
6
Number
9
Pages
1407-1414
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Significant progress has been made in understanding the molecular pathogenesis of gliomas and in predicting general outcome depending on a limited set of clinical parameters and molecular markers. However, methylation of the O⁶-methylguanine DNA methyltransferase (MGMT) gene promoter is the only molecular marker linked to sensitivity of a specific treatment, that is, alkylating agent chemotherapy, and this predictive value may be limited to glioblastoma. Moreover, in the absence of potent alternative drugs, temozolomide chemotherapy should not be withheld from patients with newly diagnosed glioblastoma without MGMT promoter methylation in general practice. In the context of clinical trials, however, irrespective of whether classical cytotoxic drugs, tyrosine kinase inhibitors or antiangiogenic agents are used, tissue should be centrally collected. Appropriate research programs should seek to define enriched patient populations for future trials and ultimately facilitate individualized cancer treatments.

Keywords
Antineoplastic Agents/therapeutic use, Biomarkers, Tumor/analysis, Biomarkers, Tumor/genetics, Brain Neoplasms/drug therapy, Brain Neoplasms/genetics, Clinical Trials as Topic, DNA Methylation, DNA Modification Methylases/genetics, DNA Repair Enzymes/genetics, Dacarbazine/analogs & derivatives, Dacarbazine/therapeutic use, Drug Resistance, Neoplasm/genetics, Glioblastoma/drug therapy, Glioblastoma/genetics, Humans, Precision Medicine/methods, Tumor Suppressor Proteins/genetics
Pubmed
Web of science
Create date
11/11/2010 9:41
Last modification date
20/08/2019 16:28
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