Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing

Singh,  S.; Soe,  S.; Roussilhon,  C.; Corradin,  G.; Druilhe,  P.

doi:10.1128/IAI.73.2.1235-1238.2005

Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing

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Serval ID

serval:BIB_FE00C0459D25

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Plasmodium falciparum merozoite surface protein 6 displays multiple targets for naturally occurring antibodies that mediate monocyte-dependent parasite killing

Journal

Infection and Immunity

Author(s)

Singh S., Soe S., Roussilhon C., Corradin G., Druilhe P.

ISSN

0019-9567 (Print)

Publication state

Published

Issued date

02/2005

Volume

Number

Pages

1235-8

Notes

Journal Article --- Old month value: Feb

Abstract

Plasmodium falciparum MSP6 is a merozoite surface antigen that shows organization and sequence homologies similar to those of MSP3. Within its C-terminus conserved region, it presents some epitopes that are cross-reactive with MSP3 and others that are not, both being targets of naturally occurring antibodies that block the P. falciparum erythrocytic cycle in cooperation with monocytes.

Keywords

Amino Acid Sequence Animals Antibodies/*immunology Antigens, Protozoan/immunology Epitopes/immunology Humans Malaria, Falciparum/*immunology Membrane Proteins/*immunology Molecular Sequence Data Monocytes/*immunology Plasmodium falciparum/*immunology Protozoan Proteins/*immunology

OAI-PMH

oai:serval.unil.ch:BIB_FE00C0459D25

DOI

10.1128/IAI.73.2.1235-1238.2005

Pubmed

15664972

Web of science

000226731700069

Open Access

Yes

Create date

24/01/2008 14:55