Swiss Evaluation Registry for Pediatric Infective Endocarditis (SERPIE) - Risk factors for complications in children and adolescents with infective endocarditis.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_FDDF74C2FF21
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Swiss Evaluation Registry for Pediatric Infective Endocarditis (SERPIE) - Risk factors for complications in children and adolescents with infective endocarditis.
Journal
International journal of cardiology
Author(s)
Schuler S.K., Crisinel P.A., Joye R., Rohr M., Bressieux-Degueldre S., Glöckler M., Paioni P., Agyeman PKA, Knirsch W.
ISSN
1874-1754 (Electronic)
ISSN-L
0167-5273
Publication state
Published
Issued date
01/01/2023
Peer-reviewed
Oui
Volume
370
Pages
463-471
Language
english
Notes
Publication types: Multicenter Study ; Journal Article
Publication Status: ppublish
Abstract
Infective endocarditis (IE) in pediatric patients is a severe cardiac disease and its actual epidemiology and clinical outcome in Switzerland is scarcely studied.
Retrospective nationwide multicenter data analysis of pediatric IE in children (<18 years) between 2011 and 2020.
69 patients were treated for definite (40/69;58%) or possible IE (29/69;42%). 61% (42/69) were male. Diagnosis was made at median 6.4 years (IQR 0.8-12.6) of age with 19 patients (28%) during the first year of life. 84% (58/69) had congenital heart defects. IE was located on pulmonary (25/69;35%), mitral (10/69;14%), tricuspid (8/69;12%) and aortic valve (6/69;9%), and rarely on ventricular septal defect (VSD;4/69;6%) and atrial septal defect (ASD;1/69;1%). In 22% (16/69) localization was unknown. 70% (48/69) had postoperative IE, with prosthetic material involved in 60% (29/48; right ventricular to pulmonary artery conduit (24), VSD (4), ASD (1)). Causative organisms were mostly Staphylococci spp. (25;36%) including Staphylococcus aureus (19;28%), and Streptococci spp. (13;19%). 51% (35/69) suffered from severe complications including congestive heart failure (16;23%), sepsis (17;25%) and embolism (19;28%). Staphylococcus aureus was found as a predictor of severe complications in univariate and multivariate analysis (p = 0.02 and p = 0.033). In 46% (32/69) cardiac surgery was performed. 7% (5/69) died.
IE in childhood remains a severe cardiac disease with relevant mortality. The high morbidity and high rate of complications is associated with Staphylococcus aureus infections. Congenital heart defects act as a risk factor for IE, in particular the high number of cases associated with prosthetic pulmonary valve needs further evaluation and therapeutic alternatives.
Keywords
Adolescent, Child, Humans, Male, Female, Retrospective Studies, Endocarditis, Bacterial/diagnosis, Endocarditis, Bacterial/epidemiology, Endocarditis, Bacterial/surgery, Endocarditis/diagnosis, Endocarditis/epidemiology, Staphylococcal Infections/diagnosis, Staphylococcal Infections/epidemiology, Staphylococcus aureus, Heart Defects, Congenital/surgery, Risk Factors, Heart Septal Defects, Ventricular/diagnosis, Heart Septal Defects, Ventricular/epidemiology, Heart Septal Defects, Ventricular/surgery, Complication, Congenital heart disease, Infective endocarditis
Pubmed
Web of science
Open Access
Yes
Create date
23/11/2022 8:59
Last modification date
16/03/2023 6:47
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