Blockade of C5 in Severe Acute Postinfectious Glomerulonephritis Associated With Anti-Factor H Autoantibody.

Détails

ID Serval
serval:BIB_FDAC08A45996
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Blockade of C5 in Severe Acute Postinfectious Glomerulonephritis Associated With Anti-Factor H Autoantibody.
Périodique
American journal of kidney diseases : the official journal of the National Kidney Foundation
Auteur(s)
Chehade H., Rotman S., Frémeaux-Bacchi V., Aubert V., Sadallah S., Sifaki L., Salomon R., Pascual M.
ISSN
1523-6838 (Electronic)
ISSN-L
0272-6386
Statut éditorial
Publié
Date de publication
12/2016
Peer-reviewed
Oui
Volume
68
Numéro
6
Pages
944-948
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Activation of the complement cascade plays an important role in the pathogenesis of postinfectious glomerulonephritis. We report successful terminal complement pathway blockade using an anti-C5 monoclonal antibody (eculizumab) in an 8-year-old child with severe acute postinfectious glomerulonephritis requiring hemodialysis. The child presented with clinical, serologic, and histopathologic criteria for diffuse crescentic postinfectious glomerulonephritis. Complement measurements showed low C3 and C4 levels, with increased SC5b-9 titers. The presence of a transient anti-factor H autoantibody was also identified. Eculizumab (600mg, 2 doses at a 1-week interval) was administered, with a striking recovery of kidney function. There were no additional hemodialysis sessions needed after the first dose of eculizumab, and glomerular filtration rate measured using inulin clearance at 12 months of follow-up was within the normal range (92mL/min/1.73m(2)). Prompt terminal complement blockade may have improved the outcome in this case of severe acute postinfectious glomerulonephritis.

Pubmed
Web of science
Création de la notice
11/10/2016 17:26
Dernière modification de la notice
20/08/2019 16:28
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