Anatomical localization of corticotropin-releasing activity in the human brain
Details
Serval ID
serval:BIB_FD83D661759A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Anatomical localization of corticotropin-releasing activity in the human brain
Journal
Life Sciences
ISSN
0024-3205 (Print)
Publication state
Published
Issued date
12/1986
Volume
39
Number
25
Pages
2475-81
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 22
Research Support, Non-U.S. Gov't --- Old month value: Dec 22
Abstract
Corticotropin-releasing activity (CRa) and arginine-vasopressin (AVP) content were measured in seven human hypothalami. The hypothalami were obtained from routine autopsy of patients suffering from no obvious neuroendocrinological abnormality. Twelve distinct hypothalamic areas were dissected in the frozen state and extracted in aqueous solution. CRa was measured by a bioassay measuring the aCTH released by rat pituitary cells in vitro, and vasopressin by direct radioimmunoassay. CRa was detectable in almost every area with the highest values in the supraoptic, paraventricular and infundibular (arcuate) areas. Vasopressin concentrations were maximum in the supraoptic nucleus, followed by the paraventricular and infundibular nuclei. We conclude that: hypothalami obtained from routine autopsy at a general hospital can be used for consistent CRa and vasopressin assay. Vasopressin and CRa are similarly distributed in man and in the rat. In both species, high CRa, which is not explained by AVP, is found in the paraventricular nucleus. The infundibular (arcuate) nucleus seems to display non AVP-dependent CRa much greater in the human than in the rat.
Keywords
Adrenocorticotropic Hormone/*metabolism
Aged
Arginine Vasopressin/*metabolism
Autopsy
Biological Assay
Brain/*metabolism
Brain Mapping
Humans
Hypothalamus/anatomy & histology/*metabolism
Middle Aged
Radioimmunoassay
Tissue Distribution
Pubmed
Web of science
Create date
15/02/2008 17:58
Last modification date
20/08/2019 17:28