Lipid-loaded macrophages as new therapeutic target in cancer.

Details

Ressource 1Download: 35798535_BIB_FD2BFB720D7B.pdf (1423.61 [Ko])
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_FD2BFB720D7B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lipid-loaded macrophages as new therapeutic target in cancer.
Journal
Journal for immunotherapy of cancer
Author(s)
Marelli G., Morina N., Portale F., Pandini M., Iovino M., Di Conza G., Ho P.C., Di Mitri D.
ISSN
2051-1426 (Electronic)
ISSN-L
2051-1426
Publication state
Published
Issued date
07/2022
Peer-reviewed
Oui
Volume
10
Number
7
Pages
e004584
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Macrophages are main players of the innate immune system. They show great heterogeneity and play diverse functions that include support to development, sustenance of tissue homeostasis and defense against infections. Dysfunctional macrophages have been described in multiple pathologies including cancer. Indeed tumor-associated macrophages (TAMs) are abundant in most tumors and sustain cancer growth, promote invasion and mediate immune evasion. Importantly, lipid metabolism influences macrophage activation and lipid accumulation confers pathogenic features on macrophages. Notably, a subset of lipid-loaded macrophages has been recently identified in many tumor types. Lipid-loaded TAMs support tumor growth and progression and exert immune-suppressive activities. In this review, we describe the role of lipid metabolism in macrophage activation in physiology and pathology and we discuss the impact of lipid accumulation in macrophages in the context of cancer.
Keywords
Humans, Lipids, Macrophages, Neoplasms, Tumor Microenvironment, Immunomodulation, Metabolic Networks and Pathways
Pubmed
Web of science
Open Access
Yes
Create date
19/07/2022 13:03
Last modification date
25/01/2024 7:48
Usage data