Interplays between mouse mammary tumor virus and the cellular and humoral immune response.

Détails

ID Serval
serval:BIB_FD0A307D70FA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Interplays between mouse mammary tumor virus and the cellular and humoral immune response.
Périodique
Immunological Reviews
Auteur(s)
Acha-Orbea H., Finke D., Attinger A., Schmid S., Wehrli N., Vacheron S., Xenarios I., Scarpellino L., Toellner K.M., MacLennan I.C., Luther S.A.
ISSN
0105-2896 (Print)
ISSN-L
0105-2896
Statut éditorial
Publié
Date de publication
1999
Volume
168
Pages
287-303
Langue
anglais
Résumé
Mouse mammary tumor virus has developed strategies to exploit the immune response. It requires vigorous immune stimulation to achieve efficient infection. The infected antigen-presenting cells present a viral superantigen on the cell surface which stimulates strong CD4-mediated T-cell help but CD8 T-cell responses are undetectable. Despite the high frequency of superantigen-reactive T cells, the superantigen-induced immune response is comparable to classical antigen responses in terms of T-cell priming, T-cell-B-cell collaboration as well as follicular and extra-follicular B-cell differentiation. Induction of systemic anergy is observed, similar to classical antigen responses where antigen is administered systemically but does not influence the role of the superantigen-reactive T cells in the maintenance of the chronic germinal center reaction. So far we have been unable to detect a cytotoxic T-cell response to mouse mammary tumor virus peptide antigens or to the superantigen. This might yet represent another step in the viral infection strategy.
Mots-clé
Amino Acid Sequence, Animals, Antibody Formation, Antigen-Presenting Cells/immunology, Antigens, Viral/immunology, Humans, Immunity, Cellular, Mammary Tumor Virus, Mouse/immunology, Mice, Molecular Sequence Data, Retroviridae Infections/immunology, Superantigens/immunology, T-Lymphocytes/immunology, T-Lymphocytes, Cytotoxic/immunology, Tumor Virus Infections/immunology, Virus Diseases/immunology
Pubmed
Web of science
Création de la notice
24/01/2008 14:48
Dernière modification de la notice
20/08/2019 16:28
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