Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Neonatal renal dysfunction and intrauterine exposure to prostaglandin synthesis inhibitors.
European Journal of Pediatrics
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Three cases of renal dysfunction at birth were observed in premature babies exposed in utero to prostaglandin synthetase inhibitors (PSI) and corticosteroids. Transient water and sodium retention with uraemia occurred in one patient, and severe acute renal failure with marked hyperkalaemia in twins. These findings may be due to impairment of prostaglandin (PG)-mediated renal adaptation to stress conditions after transplacental passage of PSI. Corticosteroids may also have affected PG synthesis inhibition.
Acute Kidney Injury/chemically induced, Anti-Inflammatory Agents, Non-Steroidal/administration & dosage, Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Betamethasone/adverse effects, Cesarean Section, Cyclooxygenase Inhibitors, Diseases in Twins, Drug Therapy, Combination, Female, Humans, Indomethacin/adverse effects, Infant, Newborn, Infant, Premature, Diseases/chemically induced, Ketoprofen/adverse effects, Kidney Function Tests, Male, Obstetric Labor, Premature/prevention & control, Pregnancy
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