HAMAP in 2013, new developments in the protein family classification and annotation system.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_FC26D17A3984
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
HAMAP in 2013, new developments in the protein family classification and annotation system.
Périodique
Nucleic Acids Research
Auteur(s)
Pedruzzi I., Rivoire C., Auchincloss A.H., Coudert E., Keller G., de Castro E., Baratin D., Cuche B.A., Bougueleret L., Poux S., Redaschi N., Xenarios I., Bridge A.
Collaborateur(s)
the UniProt Consortium
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
2013
Volume
41
Numéro
D1
Pages
D584-D589
Langue
anglais
Résumé
HAMAP (High-quality Automated and Manual Annotation of Proteins-available at http://hamap.expasy.org/) is a system for the classification and annotation of protein sequences. It consists of a collection of manually curated family profiles for protein classification, and associated annotation rules that specify annotations that apply to family members. HAMAP was originally developed to support the manual curation of UniProtKB/Swiss-Prot records describing microbial proteins. Here we describe new developments in HAMAP, including the extension of HAMAP to eukaryotic proteins, the use of HAMAP in the automated annotation of UniProtKB/TrEMBL, providing high-quality annotation for millions of protein sequences, and the future integration of HAMAP into a unified system for UniProtKB annotation, UniRule. HAMAP is continuously updated by expert curators with new family profiles and annotation rules as new protein families are characterized. The collection of HAMAP family classification profiles and annotation rules can be browsed and viewed on the HAMAP website, which also provides an interface to scan user sequences against HAMAP profiles.
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/01/2013 21:38
Dernière modification de la notice
16/09/2019 5:26
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