HAMAP in 2013, new developments in the protein family classification and annotation system.

Details

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State: Public
Version: Final published version
Serval ID
serval:BIB_FC26D17A3984
Type
Article: article from journal or magazin.
Collection
Publications
Title
HAMAP in 2013, new developments in the protein family classification and annotation system.
Journal
Nucleic Acids Research
Author(s)
Pedruzzi I., Rivoire C., Auchincloss A.H., Coudert E., Keller G., de Castro E., Baratin D., Cuche B.A., Bougueleret L., Poux S., Redaschi N., Xenarios I., Bridge A.
Working group(s)
the UniProt Consortium
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
2013
Volume
41
Number
D1
Pages
D584-D589
Language
english
Abstract
HAMAP (High-quality Automated and Manual Annotation of Proteins-available at http://hamap.expasy.org/) is a system for the classification and annotation of protein sequences. It consists of a collection of manually curated family profiles for protein classification, and associated annotation rules that specify annotations that apply to family members. HAMAP was originally developed to support the manual curation of UniProtKB/Swiss-Prot records describing microbial proteins. Here we describe new developments in HAMAP, including the extension of HAMAP to eukaryotic proteins, the use of HAMAP in the automated annotation of UniProtKB/TrEMBL, providing high-quality annotation for millions of protein sequences, and the future integration of HAMAP into a unified system for UniProtKB annotation, UniRule. HAMAP is continuously updated by expert curators with new family profiles and annotation rules as new protein families are characterized. The collection of HAMAP family classification profiles and annotation rules can be browsed and viewed on the HAMAP website, which also provides an interface to scan user sequences against HAMAP profiles.
Pubmed
Web of science
Open Access
Yes
Create date
15/01/2013 21:38
Last modification date
16/09/2019 5:26
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