Assessment of pathological response to therapy using lipid mass spectrometry imaging.

Détails

Ressource 1Télécharger: pmid27841360.pdf (2676.79 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_FBF667648512
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Assessment of pathological response to therapy using lipid mass spectrometry imaging.
Périodique
Scientific reports
Auteur(s)
Patterson N.H., Alabdulkarim B., Lazaris A., Thomas A., Marcinkiewicz M.M., Gao Z.H., Vermeulen P.B., Chaurand P., Metrakos P.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Statut éditorial
Publié
Date de publication
14/11/2016
Peer-reviewed
Oui
Volume
6
Pages
36814
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response' to a given therapy. However, histopathological assessment of pathological response remains subjective. Here we use MALDI mass spectrometry imaging to generate lipid signatures from colorectal cancer liver metastasis specimens resected from patients preoperatively treated with chemotherapy. Using these signatures we obtained a unique pathological response score that correlates with prognosis. In addition, we identify single lipid moieties that are overexpressed in different histopathological features of the tumor, which have potential as new biomarkers for assessing response to therapy. These data show that computational methods, focusing on the lipidome, can be used to determine prognostic markers for response to chemotherapy and may potentially improve risk assessment and patient care.
Mots-clé
Adult, Aged, Aged, 80 and over, Biomarkers, Tumor/analysis, Chemotherapy, Adjuvant/methods, Colorectal Neoplasms/diagnostic imaging, Colorectal Neoplasms/drug therapy, Colorectal Neoplasms/metabolism, Colorectal Neoplasms/pathology, Female, Humans, Lipids/analysis, Liver Neoplasms/diagnostic imaging, Liver Neoplasms/drug therapy, Liver Neoplasms/metabolism, Liver Neoplasms/secondary, Male, Middle Aged, Prognosis, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/11/2016 13:41
Dernière modification de la notice
20/08/2019 16:27
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