Frequency and prognostic impact of acute kidney injury in patients with acute pulmonary embolism. Data from the RIETE registry.

Détails

ID Serval
serval:BIB_FBBA183D678A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Frequency and prognostic impact of acute kidney injury in patients with acute pulmonary embolism. Data from the RIETE registry.
Périodique
International journal of cardiology
Auteur(s)
Murgier M., Bertoletti L., Darmon M., Zeni F., Valle R., Del Toro J., Llamas P., Mazzolai L., Villalobos A., Monreal M.
Collaborateur(s)
RIETE Investigators
ISSN
1874-1754 (Electronic)
ISSN-L
0167-5273
Statut éditorial
Publié
Date de publication
15/09/2019
Peer-reviewed
Oui
Volume
291
Pages
121-126
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Acute kidney injury (AKI) is associated with a poor outcome. Although pulmonary embolism (PE) may promote AKI through renal congestion and/or hemodynamic instability, its frequency and influence on outcome in patients with acute PE have been poorly studied.
The frequency of AKI (defined according to the "Kidney Disease: Improving Global Outcomes" definition) at baseline and its influence on the 30-day mortality was evaluated in patients with acute PE from the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry. We used multivariate analysis to assess whether the presence of AKI influenced the risk for 30-day death.
The study included 21,131 patients, of whom 6222 (29.5%) had AKI at baseline: 4385 patients (21%) in stage 1, 1385 (6.5%) in stage 2 and 452 (2%) in stage 3. The proportion of patients with high-risk PE in those with no AKI, AKI stage 1, AKI stage 2 or AKI stage 3 was: 2.8%, 5.3%, 8.8% and 12%, respectively (p < 0.001). After 30 days, 1236 patients (5.9%) died. Overall mortality was 4% in patients with no AKI, 8.4% in AKI stage 1, 14% in AKI stage 2 and 17% in AKI stage 3 (all p < 0.001). AKI was independently associated with an increased risk of all-cause death at 30 days (odds ratio = 1.25; 95%CI: 1.02-1.54).
One in every 3-4 patients with acute PE had AKI at baseline. The presence of AKI independently predicted 30-day mortality. This study suggests that AKI may deserve to be evaluated as a prognostic factor in patients with acute PE.
Mots-clé
Acute kidney injury, Biomarkers, Bleeding, Mortality, Pulmonary embolism, Risk
Pubmed
Web of science
Création de la notice
18/06/2019 16:16
Dernière modification de la notice
25/09/2019 5:11
Données d'usage