Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

Détails

ID Serval
serval:BIB_FBB52AEAFE2C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Complementary DNA cloning of complement C8 beta and its sequence homology to C9.
Périodique
Biochemistry
Auteur(s)
Haefliger J.A., Tschopp J., Nardelli D., Wahli W., Kocher H.P., Tosi M., Stanley K.K.
ISSN
0006-2960 (Print)
ISSN-L
0006-2960
Statut éditorial
Publié
Date de publication
06/1987
Volume
26
Numéro
12
Pages
3551-3556
Langue
anglais
Résumé
The complete amino acid sequence of mature C8 beta has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions. In particular, the cysteine-rich domains and membrane-inserting regions of C9 are well conserved. These findings are discussed in relation to a possible mechanism of membrane attack complex formation.
Mots-clé
Amino Acid Sequence, Base Sequence, Cloning, Molecular, Complement C8/genetics, Complement C9/genetics, DNA/analysis, Humans, Liver/metabolism, Macromolecular Substances, Sequence Homology, Nucleic Acid
Pubmed
Web of science
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 17:26
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