Mortality associated with diabetes and cardiovascular disease in older women.

Détails

Ressource 1Télécharger: BIB_FB801CADCA1F.P001.pdf (220.40 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_FB801CADCA1F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mortality associated with diabetes and cardiovascular disease in older women.
Périodique
Plos One
Auteur(s)
Nanchen D., Rodondi N., Cornuz J., Hillier T., Ensrud K.E., Cauley J.A., Bauer D.C.
Collaborateur(s)
Study of Osteoporotic Fractures Research Group
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
7
Numéro
11
Pages
e48818
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Résumé
BACKGROUND: Current guidelines for the prevention of cardiovascular disease (CVD) recommend diabetes as a CVD risk equivalent. However, reports that have examined the risk of diabetes in comparison to pre-existing CVD are lacking among older women. We aimed to assess whether diabetes was associated with a similar risk of total and cause-specific mortality as a history of CVD in older women.
METHODOLOGY/PRINCIPAL FINDINGS: We studied 9218 women aged 68 years or older enrolled in a prospective cohort study (Study of Osteoporotic Fracture) during a mean follow-up period of 11.7 years and compared all-cause, cardiovascular and coronary heart disease mortality among 4 groups: non-diabetic women with and without existing CVD, diabetic women with and without existing CVD. Mean (SD) age of the participants was 75.2 (5.3) years, 3.5% reported diabetes and 6.8% reported existing CVD. During follow-up, 5117 women died with 36% from CVD. The multivariate adjusted risk of cardiovascular mortality was increased among both non-diabetic women with CVD (hazard ratio (HR) 2.32, 95% CI: 1.97-2.74, P<0.001) and diabetic women without CVD (HR 2.06, CI: 1.62-2.64, P<0.001) compared to non-diabetic women without existing CVD. All-cause, cardiovascular and coronary mortality of non-diabetic women with CVD were not significantly different from diabetic women without CVD.
CONCLUSIONS/SIGNIFICANCE: Older diabetic women without CVD have a similar risk of cardiovascular mortality compared to non-diabetic women with pre-existing CVD. The equivalence of diabetes and CVD seems to extend to older women, supporting current guidelines for cardiovascular prevention.
Mots-clé
Aged, Aged, 80 and over, Cardiovascular Diseases/complications, Cardiovascular Diseases/epidemiology, Diabetes Mellitus/epidemiology, Diabetes Mellitus/mortality, Female, Follow-Up Studies, Humans, Incidence, Prospective Studies, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2013 18:42
Dernière modification de la notice
20/08/2019 16:26
Données d'usage