NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.

Détails

ID Serval
serval:BIB_FB1F4EA9ABB0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.
Périodique
Journal of immunology
Auteur(s)
Radulovic K., Ayata C.K., Mak'Anyengo R., Lechner K., Wuggenig P., Kaya B., Hruz P., Gomez de Agüero M., Broz P., Weigmann B., Niess J.H.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
15/07/2019
Peer-reviewed
Oui
Volume
203
Numéro
2
Pages
544-556
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4 <sup>+</sup> T cells led to decreased survival.
Pubmed
Web of science
Création de la notice
17/06/2019 18:39
Dernière modification de la notice
21/08/2019 6:36
Données d'usage