Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.

Détails

ID Serval
serval:BIB_FB03C7981490
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.
Périodique
Journal of Clinical Investigation
Auteur(s)
Fajas L., Annicotte J.S., Miard S., Sarruf D., Watanabe M., Auwerx J.
ISSN
0021-9738 (Print)
ISSN-L
0021-9738
Statut éditorial
Publié
Date de publication
2004
Volume
113
Numéro
9
Pages
1288-1295
Langue
anglais
Résumé
We evaluated the effects of E2F1 on glucose homeostasis using E2F1(-/-) mice. E2F1(-/-) mice show an overall reduction in pancreatic size as the result of impaired postnatal pancreatic growth. Furthermore, these animals have dysfunctional beta cells, linked to impaired PDX-1 activity. Because of the disproportionate small pancreas and dysfunctional islets, E2F1(-/-) mice secrete insufficient amounts of insulin in response to a glucose load, resulting in glucose intolerance. Despite this glucose intolerance, E2F1(-/-) mice do not develop overt diabetes mellitus because they have insulin hypersensitivity, which is secondary to a diminished adipose tissue mass and altered adipocytokine levels, which compensates for the defect in insulin secretion. These data demonstrate that factors controlling cell proliferation, such as E2F1, determine pancreatic growth and function, subsequently affecting metabolic homeostasis.
Mots-clé
Adaptor Proteins, Signal Transducing, Adipocytes/cytology, Adipocytes/metabolism, Animals, Apoptosis, Blood Glucose/metabolism, Carrier Proteins/metabolism, Cell Division, Gene Expression Regulation, Glucose/metabolism, Glucose Intolerance, Homeodomain Proteins, Homeostasis, Insulin/blood, Insulin/secretion, Islets of Langerhans/cytology, Islets of Langerhans/metabolism, Leptin/blood, Male, Mice, Mice, Knockout, Muscle, Smooth/cytology, Muscle, Smooth/metabolism, Pancreas/cytology, Pancreas/growth & development, RNA-Binding Proteins, Time Factors, Trans-Activators/metabolism
Pubmed
Web of science
Création de la notice
07/03/2013 17:04
Dernière modification de la notice
03/03/2018 22:57
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