Are protozoan metacaspases potential parasite killers?

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State: Public
Version: author
Serval ID
serval:BIB_FAEC08ECD46B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Are protozoan metacaspases potential parasite killers?
Journal
Parasites and Vectors
Author(s)
Meslin B., Zalila H., Fasel N., Picot S., Bienvenu A.L.
ISSN
1756-3305 (Electronic)
ISSN-L
1756-3305
Publication state
Published
Issued date
2011
Volume
4
Pages
26-32
Language
english
Abstract
Mechanisms concerning life or death decisions in protozoan parasites are still imperfectly understood. Comparison with higher eukaryotes has led to the hypothesis that caspase-like enzymes could be involved in death pathways. This hypothesis was reinforced by the description of caspase-related sequences in the genome of several parasites, including Plasmodium, Trypanosoma and Leishmania. Although several teams are working to decipher the exact role of metacaspases in protozoan parasites, partial, conflicting or negative results have been obtained with respect to the relationship between protozoan metacaspases and cell death. The aim of this paper is to review current knowledge of protozoan parasite metacaspases within a drug targeting perspective.
Keywords
Antiprotozoal Agents/metabolism, Caspases/metabolism, Cell Death, Leishmania/enzymology, Leishmania/physiology, Plasmodium/enzymology, Plasmodium/physiology, Trypanosoma/enzymology, Trypanosoma/physiology
Pubmed
Web of science
Open Access
Yes
Create date
27/10/2011 13:40
Last modification date
20/08/2019 16:26
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