Are protozoan metacaspases potential parasite killers?

Détails

Ressource 1Télécharger: BIB_FAEC08ECD46B.P001.pdf (278.08 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_FAEC08ECD46B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Are protozoan metacaspases potential parasite killers?
Périodique
Parasites and Vectors
Auteur(s)
Meslin B., Zalila H., Fasel N., Picot S., Bienvenu A.L.
ISSN
1756-3305 (Electronic)
ISSN-L
1756-3305
Statut éditorial
Publié
Date de publication
2011
Volume
4
Pages
26-32
Langue
anglais
Résumé
Mechanisms concerning life or death decisions in protozoan parasites are still imperfectly understood. Comparison with higher eukaryotes has led to the hypothesis that caspase-like enzymes could be involved in death pathways. This hypothesis was reinforced by the description of caspase-related sequences in the genome of several parasites, including Plasmodium, Trypanosoma and Leishmania. Although several teams are working to decipher the exact role of metacaspases in protozoan parasites, partial, conflicting or negative results have been obtained with respect to the relationship between protozoan metacaspases and cell death. The aim of this paper is to review current knowledge of protozoan parasite metacaspases within a drug targeting perspective.
Mots-clé
Antiprotozoal Agents/metabolism, Caspases/metabolism, Cell Death, Leishmania/enzymology, Leishmania/physiology, Plasmodium/enzymology, Plasmodium/physiology, Trypanosoma/enzymology, Trypanosoma/physiology
Pubmed
Web of science
Création de la notice
27/10/2011 14:40
Dernière modification de la notice
03/03/2018 22:56
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