Hyperphosphatémie et insuffisance rénale transitoire après chimiothérapie d'une leucémie lymphoblastique aiguë [Hyperphosphatemia and transient renal insufficiency following chemotherapy of acute lymphoblastic leukemia]

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_FAD2A73C5303
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Hyperphosphatémie et insuffisance rénale transitoire après chimiothérapie d'une leucémie lymphoblastique aiguë [Hyperphosphatemia and transient renal insufficiency following chemotherapy of acute lymphoblastic leukemia]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
Aubert J.D., Claeys M., Zwahlen A., Wauters J.P.
ISSN
0036-7672
Statut éditorial
Publié
Date de publication
1988
Peer-reviewed
Oui
Volume
118
Numéro
51
Pages
1953-1956
Langue
français
Notes
Publication types: Case Reports ; English Abstract ; Journal Article
Résumé
Acute renal failure during treatment of lymphoblastic malignancies is usually due to drug toxicity or acute uric nephropathy. Observations were recently reported where extreme hyperphosphatemia may represent another pathophysiological mechanism. We describe 2 cases, in 36- and 77-year-old women, with acute lymphoblastic leukemia. Acute renal failure was observed 2 days after cytotoxic treatment. Maximal blood creatinine values were 860 and 550 mumol/l respectively, and for phosphate 6.3 and 7.5 mmol/l. With oral phosphate binders, and after four peritoneal exchanges for the second patient, renal function gradually returned to normal values within 4 weeks. Tumor lysis syndrome with associated hyperphosphatemia is described exclusively in lymphoblastic malignancies and renal failure is probably a consequence of intratubular calcium phosphate precipitation. In this situation prophylactic administration of phosphate binders and attentive monitoring of phosphatemia are necessary.
Mots-clé
Adult, Aged, Aluminum Hydroxide, Antineoplastic Combined Chemotherapy Protocols, Creatinine, Female, Humans, Kidney Failure, Acute, Phosphates, Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pubmed
Web of science
Création de la notice
21/01/2008 13:54
Dernière modification de la notice
06/11/2018 8:08
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