Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias.

Détails

ID Serval
serval:BIB_FAC82008240A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias.
Périodique
Neuroimage
Auteur(s)
Good C.D., Scahill R.I., Fox N.C., Ashburner J., Friston K.J., Chan D., Crum W.R., Rossor M.N., Frackowiak R.S.
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2002
Volume
17
Numéro
1
Pages
29-46
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
We compared voxel-based morphometry (VBM) with independent accurate region-of-interest (ROI) measurements of temporal lobe structures in order to validate the usefulness of this fully automated and unbiased technique in Alzheimer's disease (AD) and semantic dementia (SD). In AD, ROI analyses appear more sensitive to volume loss in the amygdalae, whereas VBM analyses appear more sensitive to right middle temporal gyrus and regional hippocampal volume loss. In SD, ROI analyses appear more sensitive to left middle and inferior temporal gyrus volume loss, whereas VBM appears more sensitive to regional hippocampal volume loss. In addition the significance of volume reductions was generally less in VBM owing to more stringent corrections for multiple comparisons. In conclusion, the automated technique detects a general trend of atrophy similar to that of expertly labeled ROI measurements in AD and SD, although there are discrepancies in the ranking of severity and in the significance of volume reductions that are more marked in AD.
Mots-clé
Alzheimer Disease/cerebrospinal fluid, Alzheimer Disease/pathology, Atrophy, Brain/pathology, Dementia/cerebrospinal fluid, Dementia/pathology, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging/methods, Magnetic Resonance Imaging/statistics & numerical data, Male, Middle Aged, Nerve Degeneration/cerebrospinal fluid, Nerve Degeneration/pathology, Organ Size/physiology, Reproducibility of Results, Temporal Lobe/pathology
Pubmed
Web of science
Création de la notice
12/09/2011 18:23
Dernière modification de la notice
03/03/2018 22:56
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