Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium transport.

Détails

ID Serval
serval:BIB_FAC3750250F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium transport.
Périodique
Physiological Genomics
Auteur(s)
Studer R.A., Person E., Robinson-Rechavi M., Rossier B.C.
ISSN
1531-2267 (Electronic)
ISSN-L
1094-8341
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
43
Numéro
13
Pages
844-854
Langue
anglais
Résumé
Despite large changes in salt intake, the mammalian kidney is able to maintain the extracellular sodium concentration and osmolarity within very narrow margins, thereby controlling blood volume and blood pressure. In the aldosterone-sensitive distal nephron (ASDN), aldosterone tightly controls the activities of epithelial sodium channel (ENaC) and Na,K-ATPase, the two limiting factors in establishing transepithelial sodium transport. It has been proposed that the ENaC/degenerin gene family is restricted to Metazoans, whereas the α- and β-subunits of Na,K-ATPase have homologous genes in prokaryotes. This raises the question of the emergence of osmolarity control. By exploring recent genomic data of diverse organisms, we found that: 1) ENaC/degenerin exists in all of the Metazoans screened, including nonbilaterians and, by extension, was already present in ancestors of Metazoa; 2) ENaC/degenerin is also present in Naegleria gruberi, an eukaryotic microbe, consistent with either a vertical inheritance from the last common ancestor of Eukaryotes or a lateral transfer between Naegleria and Metazoan ancestors; and 3) The Na,K-ATPase β-subunit is restricted to Holozoa, the taxon that includes animals and their closest single-cell relatives. Since the β-subunit of Na,K-ATPase plays a key role in targeting the α-subunit to the plasma membrane and has an additional function in the formation of cell junctions, we propose that the emergence of Na,K-ATPase, together with ENaC/degenerin, is linked to the development of multicellularity in the Metazoan kingdom. The establishment of multicellularity and the associated extracellular compartment ("internal milieu") precedes the emergence of other key elements of the aldosterone signaling pathway.
Mots-clé
Acid Sensing Ion Channels, Aldosterone/metabolism, Animals, Degenerin Sodium Channels, Epithelial Sodium Channels/genetics, Evolution, Molecular, Humans, Ion Transport/drug effects, Membrane Proteins/genetics, Nerve Tissue Proteins/genetics, Phosphoproteins/genetics, Phylogeny, Sodium/metabolism, Sodium-Potassium-Exchanging ATPase/genetics
Pubmed
Web of science
Création de la notice
05/05/2011 16:35
Dernière modification de la notice
03/03/2018 22:56
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