Measurement of cerebral monoamine oxidase B activity using L-[11C]deprenyl and dynamic positron emission tomography.

Détails

ID Serval
serval:BIB_FABB910407F6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Measurement of cerebral monoamine oxidase B activity using L-[11C]deprenyl and dynamic positron emission tomography.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Lammertsma A.A., Bench C.J., Price G.W., Cremer J.E., Luthra S.K., Turton D., Wood N.D., Frackowiak R.S.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
1991
Volume
11
Numéro
4
Pages
545-556
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
A tracer kinetic procedure was developed for the measurement of monoamine oxidase type B (MAO-B) activity using L-[11C]deprenyl and positron emission tomography (PET). The kinetic model consisted of two tissue compartments with irreversible binding to the second compartment (three rate constants). In addition, a blood volume component was included. Special attention was given to the accurate measurement of the plasma and whole blood input functions. The method was applied to the measurement of the dose-response curve of a reversible MAO-B inhibitor (Ro 19-6327). From the results, it followed that the rate constant for irreversible binding (k3) appeared to be a better index of MAO-B activity than the net influx constant Ki. Furthermore, regional analysis demonstrated that Ki, but not k3, was flow dependent. This implies that full kinetic analysis is required for an accurate assessment of MAO-B activity.
Mots-clé
Aged, Brain/enzymology, Female, Humans, Kinetics, Male, Middle Aged, Monoamine Oxidase/metabolism, Monoamine Oxidase Inhibitors/pharmacology, Picolinic Acids/pharmacology, Selegiline/metabolism, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
25/09/2011 17:56
Dernière modification de la notice
03/03/2018 22:56
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