Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.

Détails

ID Serval
serval:BIB_FABB87E80824
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.
Périodique
Endocrine Pathology
Auteur(s)
La Rosa S., Bernasconi B., Micello D., Finzi G., Capella C.
ISSN
1046-3976 (Print)
ISSN-L
1046-3976
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
20
Numéro
1
Pages
24-34
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
Poorly differentiated neuroendocrine carcinomas (PDNECs) of the kidney are extremely rare high-grade cancers accounting for only 42 cases reported in the literature. In this paper, we describe the morphological, immunohistochemical, ultrastructural, and for the first time, cytogenetic features of a renal PDNEC. In addition, we have reviewed the literature and compared the published clinicopathological data with our morphological and genetic results. The tumor arose within the kidney parenchyma and showed the typical histological features of a pure small cell PDNEC. Fluorescence in situ hybridization study demonstrated a complex chromosomal assessment indicative of a high degree of chromosome instability with gain of multiple chromosomes, loss of p53, and amplification of myc gene. These results suggest that renal PDNEC has a different genetic background to renal clear cell carcinoma, mainly characterized by the loss of the short arm of chromosome 3. Conversely, genetic alterations seem to resemble those of type 2 papillary renal cell carcinoma. The review of the literature demonstrated that PDNECs are associated with poor prognosis and that parenchymal tumors show some differences from those arising in the pelvis, in that parenchymal tumors are purely neuroendocrine while pelvic tumors are mostly mixed neuroendocrine-exocrine neoplasms.
Mots-clé
Aged, 80 and over, Carcinoma, Neuroendocrine/genetics, Carcinoma, Neuroendocrine/metabolism, Carcinoma, Small Cell/genetics, Carcinoma, Small Cell/metabolism, Cytogenetics, Gene Amplification, Genes, myc, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Kidney Neoplasms/genetics, Kidney Neoplasms/metabolism, Male, Microscopy, Electron, Transmission, Tumor Suppressor Protein p53/genetics
Pubmed
Web of science
Création de la notice
06/09/2016 15:00
Dernière modification de la notice
03/03/2018 22:56
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