Neural correlates of motor recovery after stroke: a longitudinal fMRI study.

Détails

ID Serval
serval:BIB_FA98404C9CCD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neural correlates of motor recovery after stroke: a longitudinal fMRI study.
Périodique
Brain
Auteur(s)
Ward N.S., Brown M.M., Thompson A.J., Frackowiak R.S.
ISSN
0006-8950 (Print)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
2003
Volume
126
Numéro
Pt 11
Pages
2476-2496
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Recovery of motor function after stroke may occur over weeks or months and is often attributed to cerebral reorganization. We have investigated the longitudinal relationship between recovery after stroke and task-related brain activation during a motor task as measured using functional MRI (fMRI). Eight first-ever stroke patients presenting with hemiparesis resulting from cerebral infarction sparing the primary motor cortex, and four control subjects were recruited. Subjects were scanned on a number of occasions whilst performing an isometric dynamic visually paced hand grip task. Recovery in the patient group was assessed using a battery of outcome measures at each time point. Task-related brain activations decreased over sessions as a function of recovery in a number of primary and non-primary motor regions in all patients, but no session effects were seen in the controls. Furthermore, consistent decreases across sessions correlating with recovery were seen across the whole patient group independent of rate of recovery or initial severity, in primary motor cortex, premotor and prefrontal cortex, supplementary motor areas, cingulate sulcus, temporal lobe, striate cortex, cerebellum, thalamus and basal ganglia. Although recovery-related increases were seen in different brain regions in four patients, there were no consistent effects across the group. These results further our understanding of the recovery process by demonstrating for the first time a clear temporal relationship between recovery and task-related activation of the motor system after stroke.
Mots-clé
Adult, Aged, Brain/pathology, Brain/physiopathology, Cerebral Infarction/pathology, Cerebral Infarction/physiopathology, Female, Hand Strength, Humans, Image Processing, Computer-Assisted/methods, Longitudinal Studies, Magnetic Resonance Imaging/methods, Male, Middle Aged, Motor Cortex/pathology, Motor Cortex/physiopathology, Motor Skills, Neuronal Plasticity, Psychomotor Performance, Recovery of Function
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/09/2011 19:40
Dernière modification de la notice
09/05/2019 3:48
Données d'usage