Angiotensin II stimulates the release of ACTH from dispersed rat anterior pituitary cells

Details

Serval ID
serval:BIB_FA9645D0ADE2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Angiotensin II stimulates the release of ACTH from dispersed rat anterior pituitary cells
Journal
Clinical Endocrinology
Author(s)
Gaillard  R. C., Grossman  A., Gillies  G., Rees  L. H., Besser  G. M.
ISSN
0300-0664 (Print)
Publication state
Published
Issued date
12/1981
Volume
15
Number
6
Pages
573-8
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
In a rat anterior pituitary dispersed cell system, angiotensin II was found to stimulate the release of ACTH at concentrations ranging from 100 pmol/l to 1 mumol/l, with a maximal response being given by 10 nmol/l. The angiotensin II antagonist, saralasin, was able to block completely at a concentration of 1 mumol/l the stimulation of ACTH induced by 10 nmol/l angiotensin II, but had no effect on the basal release. The log dose-response curve for ACTH release by angiotensin II was shifted to the right in a parallel fashion by saralasin 10 nmol/l, suggesting competitive antagonism. The stimulation of ACTH release by a rat stalk-median eminence extract or by arginine vasopressin was unaffected by saralasin. The data are interpreted as suggesting that rat corticotrophs contain angiotensin II receptors, and that these may be involved in ACTH release in response to hypovolaemic stress.
Keywords
Adrenocorticotropic Hormone/*secretion Angiotensin II/*pharmacology Animals Dose-Response Relationship, Drug Female Pituitary Gland, Anterior/cytology/*drug effects Rats Rats, Inbred Strains Saralasin/pharmacology Stimulation, Chemical
Pubmed
Web of science
Create date
15/02/2008 16:58
Last modification date
20/08/2019 16:26
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