Epinephrine, glucose, and lactate infusion in exercising adrenodemedullated rats

Détails

ID Serval
serval:BIB_FA8264F97FAB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Epinephrine, glucose, and lactate infusion in exercising adrenodemedullated rats
Périodique
Journal of Applied Physiology
Auteur(s)
Winder  W. W., Yang  H. T., Jaussi  A. W., Hopkins  C. R.
ISSN
8750-7587 (Print)
Statut éditorial
Publié
Date de publication
04/1987
Volume
62
Numéro
4
Pages
1442-7
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Apr
Résumé
The purpose of this study was to determine the metabolic function of the marked increase in plasma epinephrine which occurs in fasted rats during treadmill exercise. Fasted adrenodemedullated (ADM) and sham-operated (SHAM) rats were run on a rodent treadmill (21 m/min, 15% grade) for 30 min or until exhaustion. ADM rats were infused with saline, epinephrine, glucose, or lactate during the exercise bouts. ADM saline-infused rats showed markedly reduced endurance, hypoglycemia, elevated plasma insulin, reduced blood lactate, and reduced muscle glycogenolysis compared with exercising SHAM's. Epinephrine infusion corrected all deficiencies. Glucose infusion restored endurance run times and blood glucose to normal without correcting the deficiencies in blood lactate and muscle glycogenolysis. Infusion of lactate partially corrected the hypoglycemia at 30 min of exercise, but endurance was not restored to normal and rats were hypoglycemic at exhaustion. We conclude that in the fasted exercising rat, actions of epinephrine in addition to provision of gluconeogenic substrate are essential for preventing hypoglycemia and allowing the rat to run for long periods of time.
Mots-clé
Adrenal Medulla *Adrenalectomy Animals Blood Glucose/analysis Epinephrine/blood/*pharmacology *Exertion Fatty Acids, Nonesterified/blood Glucagon/blood Glucose/*pharmacology Glycogen/metabolism Infusions, Intravenous Insulin/blood Lactates/*pharmacology Lactic Acid Liver/metabolism Male Muscles/metabolism Rats Rats, Inbred Strains
Pubmed
Web of science
Création de la notice
28/01/2008 12:53
Dernière modification de la notice
03/03/2018 22:56
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