The Effect and Safety of Prostaglandin Administration in Pediatric Liver Transplantation.

Détails

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Etat: Serval
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_FA5E09B05839
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Effect and Safety of Prostaglandin Administration in Pediatric Liver Transplantation.
Périodique
Transplantation direct
Auteur(s)
Lironi C., McLin V.A., Wildhaber B.E.
ISSN
2373-8731 (Print)
ISSN-L
2373-8731
Statut éditorial
Publié
Date de publication
06/2017
Peer-reviewed
Oui
Volume
3
Numéro
6
Pages
e163
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Prostaglandins are often administered after liver transplantation (LT) to diminish ischemia-reperfusion injury (IRI), to favor liver recovery and to prevent vascular thrombosis. Possible beneficial effects in adult liver recipients are controversial, but the single existing pediatric small case series shows no significant impact of prostaglandin administration after LT. The purpose of this study was to analyze the effect of the prostaglandin dinoprostone in pediatric liver recipients.
A retrospective analysis of 41 children (<16 years) who underwent LT between March 2008 and December 2013 was performed. Dinoprostone was administered at a rate from 0.1 to a maximum of 0.6 μg/kg per hour immediately after LT and for a maximum of 5 days. Effect of dinoprostone on post-LT IRI and hepatic function up to 60 postoperative days and number of hypotensive episodes were analyzed.
The median cumulative dose of dinoprostone was 28 μg/kg (interquartile range, 23.2). Dinoprostone had no significant effect on post-LT liver function tests and factor V levels at any of the administered dosages. There was no significant association between the total quantity of vasopressor given and the number of hypotensive episodes observed in 8 patients. One patient showed a short-lasting hypotension, possibly related to the administration of dinoprostone.
This study did not show, at any dosage between 0.1 and 0.6 μg/kg per hour, any differences in beneficial or harmful effects of high- or low-dose dinoprostone administered immediately after pediatric LT on markers of IRI, hepatic function, or hypotension.

Pubmed
Open Access
Oui
Création de la notice
22/01/2018 12:24
Dernière modification de la notice
29/05/2019 7:10
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