Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes

Détails

ID Serval
serval:BIB_FA5BD3857587
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Jongeneel  C. V., Briant  L., Udalova  I. A., Sevin  A., Nedospasov  S. A., Cambon-Thomsen  A.
ISSN
0027-8424 (Print)
Statut éditorial
Publié
Date de publication
11/1991
Volume
88
Numéro
21
Pages
9717-21
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 1
Résumé
We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.
Mots-clé
Base Sequence Gene Frequency HLA Antigens/*genetics Haplotypes Humans Linkage (Genetics) *Major Histocompatibility Complex Molecular Sequence Data Oligonucleotides/chemistry *Polymorphism, Genetic Repetitive Sequences, Nucleic Acid Tumor Necrosis Factor-alpha/*genetics
Pubmed
Web of science
Création de la notice
24/01/2008 16:39
Dernière modification de la notice
03/03/2018 22:55
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