Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological effects of other GABA(A) receptor ligands

Détails

ID Serval
serval:BIB_FA49D05AD2A9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological effects of other GABA(A) receptor ligands
Périodique
Behavior Genetics
Auteur(s)
Rinaldi Daisy, Boutrel Benjamin, Adrien Joëlle, Venault Patrice, Chapouthier Georges
ISSN
0001-8244
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
30
Numéro
6
Pages
497
Langue
anglais
Notes
SAPHIRID:67392
Résumé
Two mouse lines were selectively bred according to their sensitivity (BS line) or resistance (BR line) to seizures induced by a single i.p. injection of methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the GABA(A) receptor benzodiazepine site. Our aim was to characterize both lines' sensitivities to various physiological effects of other ligands of the GABA(A) receptor. We measured diazepam-induced anxiolysis with the elevated plus-maze test, diazepam-induced sedation by recording the vigilance states, and picrotoxin- and pentylenetetrazol-induced seizures after i.p. injections. Results presented here show that the differential sensitivities of BS and BR lines to beta-CCM can be extended to diazepam, picrotoxin, and pentylenetetrazol, suggesting a genetic selection of a general sensitivity and resistance to several ligands of the GABA(A) receptor.
Pubmed
Web of science
Création de la notice
11/03/2008 15:07
Dernière modification de la notice
03/03/2018 22:55
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