Spatial relational learning persists following neonatal hippocampal lesions in macaque monkeys

Détails

ID Serval
serval:BIB_FA3FD3D38589
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Spatial relational learning persists following neonatal hippocampal lesions in macaque monkeys
Périodique
Nature Neuroscience
Auteur(s)
Lavenex P., Banta Lavenex P., Amaral D.G.
ISSN
1097-6256
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
10
Numéro
2
Pages
234-239
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The hippocampus is important for the acquisition of spatial representations of the environment and consequently in contextual memory. This suggests that the neural substrates underlying spatial cognition might be essential for remembering specific life episodes. Indeed, hippocampal lesions prevent spatial relational learning in adult rodents and monkeys, and result in profound amnesia in adult humans. In contrast, we show here that monkeys with neonatal hippocampal lesions learned new spatial relational information. Our experiments suggest that early hippocampal damage leads to functional brain reorganization that enables spatial information to be acquired through the use of brain regions that normally do not subserve this function.
Mots-clé
Adaptation, Physiological/physiology, Aging/physiology, Animals, Animals, Newborn, Cues, Denervation, Hippocampus/anatomy & histology, Hippocampus/growth & development, Learning/physiology, Macaca mulatta, Magnetic Resonance Imaging, Memory Disorders/etiology, Neural Pathways/anatomy & histology, Neural Pathways/growth & development, Neuronal Plasticity/physiology, Neuropsychological Tests, Psychomotor Agitation/etiology, Space Perception/physiology
Pubmed
Web of science
Création de la notice
25/10/2012 14:39
Dernière modification de la notice
03/03/2018 22:55
Données d'usage