Trials using a crossover design and ambulatory blood pressure recordings to determine the efficacy of antihypertensive agents in individual patients.

Détails

ID Serval
serval:BIB_FA3DC999C7E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Trials using a crossover design and ambulatory blood pressure recordings to determine the efficacy of antihypertensive agents in individual patients.
Périodique
Journal of hypertension. Supplement
Auteur(s)
Waeber B., Burnier M., Nussberger J., Brunner H.R.
ISSN
0952-1178
Statut éditorial
Publié
Date de publication
1990
Volume
8
Numéro
4
Pages
S37-41
Langue
anglais
Résumé
The antihypertensive effects of the beta-blocking agent betaxolol and the calcium entry blocker verapamil were compared in a crossover single-blind trial. Seventeen patients with uncomplicated essential hypertension took either betaxolol or a slow-release formulation of verapamil for two consecutive 6-week periods. The sequence of treatment phases was randomly allocated and a 2-week washout period preceded each treatment. The antihypertensive effect of the test drugs was assessed both at the physician's office and during everyday activities using a portable blood pressure recorder. The crossover design of the trial made it possible to evaluate the antihypertensive efficacy of betaxolol and verapamil both in the group as a whole and in the individual patient. The individual patient response to one of these agents was not a reliable indicator of the same patient's response to the alternative agent. Betaxolol brought both office and ambulatory recorded blood pressures under control in a larger fraction of patients than verapamil, although the magnitude of the blood pressure fall in the responders was equal for each drug. These observations stress the need for an individualized approach to the evaluation of antihypertensive therapy. The present results also demonstrate that optimal antihypertensive therapy is still a matter of trial and error. The precise methodology that ought to characterize crossover trials may make it possible to improve the therapeutic approach to hypertensive patients.
Mots-clé
Ambulatory Care, Betaxolol, Blood Pressure, Delayed-Action Preparations, Drug Administration Schedule, Humans, Hypertension, Single-Blind Method, Verapamil
Pubmed
Web of science
Création de la notice
25/01/2008 13:55
Dernière modification de la notice
20/08/2019 17:25
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