Induced normothermia attenuates cerebral metabolic distress in patients with aneurysmal subarachnoid hemorrhage and refractory Fever.

Détails

ID Serval
serval:BIB_F9F743F77757
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Induced normothermia attenuates cerebral metabolic distress in patients with aneurysmal subarachnoid hemorrhage and refractory Fever.
Périodique
Stroke
Auteur(s)
Oddo M., Frangos S., Milby A., Chen I., Maloney-Wilensky E., Murtrie E.M., Stiefel M., Kofke W.A., Le Roux P.D., Levine J.M.
ISSN
1524-4628[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
40
Numéro
5
Pages
1913-1916
Langue
anglais
Résumé
BACKGROUND AND PURPOSE: The purpose of this study was to analyze whether fever control attenuates cerebral metabolic distress after aneurysmal subarachnoid hemorrhage (SAH). METHODS: Eighteen SAH patients, who underwent intracranial pressure (ICP) and cerebral microdialysis monitoring and were treated with induced normothermia for refractory fever (body temperature >or=38.3 degrees C, despite antipyretics), were studied. Levels of microdialysate lactate/pyruvate ratio (LPR) and episodes of cerebral metabolic crisis (LPR >40) were analyzed during fever and induced normothermia, at normal and high ICP (>20 mm Hg). RESULTS: Compared to fever, induced normothermia resulted in lower LPR (40+/-24 versus 32+/-9, P<0.01) and a reduced incidence of cerebral metabolic crisis (13% versus 5%, P<0.05) at normal ICP. During episodes of high ICP, induced normothermia was associated with a similar reduction of LPR, fewer episodes of cerebral metabolic crisis (37% versus 8%, P<0.01), and lower ICP (32+/-11 versus 28+/-12 mm Hg, P<0.05). CONCLUSIONS: Fever control is associated with reduced cerebral metabolic distress in patients with SAH, irrespective of ICP.
Mots-clé
Adult, Aged, Biological Markers, Body Temperature/physiology, Brain Chemistry/physiology, Data Interpretation, Statistical, Databases, Factual, Drug Resistance, Female, Fever/complications, Fever/drug therapy, Humans, Intracranial Pressure/physiology, Male, Metabolic Diseases/therapy, Microdialysis, Middle Aged, Retrospective Studies, Subarachnoid Hemorrhage/complications, Treatment Outcome
Pubmed
Web of science
Création de la notice
09/12/2009 13:31
Dernière modification de la notice
03/03/2018 22:55
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