Exosomes from Human Periapical Cyst-MSCs: Theranostic Application in Parkinson's Disease.
Details
Serval ID
serval:BIB_F9EA775840D4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Exosomes from Human Periapical Cyst-MSCs: Theranostic Application in Parkinson's Disease.
Journal
International journal of medical sciences
ISSN
1449-1907 (Electronic)
ISSN-L
1449-1907
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
17
Number
5
Pages
657-663
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Publication Status: epublish
Abstract
The scientific community continuously strives to get new disease models, to discover early markers or novel therapeutic approaches, improving the diagnosis and prognosis of several human pathologies. Parkinson's Disease (PD) is characterized by a long asymptomatic phase, characterized by a selective loss of dopaminergic neurons. Recently, the human Periapical Cyst-Mesenchymal Stem Cells (hPCy-MSCs) have been differentiated in functional dopaminergic neurons: such oral-derived MSCs and the hPCy-MSCs-derived exosomes may represent a strategic and useful in vitro study-model, as well as intriguing therapeutic carriers. Circadian rhythm (CR) alteration variously impacts on PD pathways: an interesting research target is represented by the analysis of the exosomes released by dopaminergic neurons, derived from neural-differentiated hPCy-MSCs, after having reproduced in-vitro PD-like conditions. This review aims to describe the crosstalk among some aspects of circadian rhythm related to the onset of PD and the exosomes released by cells of PD patients. More in detail: the first part of this article will describe the main characteristics of circadian rhythm and the involvement of the exosomes found to be effective in the pathogenesis of PD. Finally, the authors will suggest how those exosomes derived from dopaminergic neurons, obtained by oral-derived stem cells (hPCy-MSCs) may represent a smart model for the in vitro research on PD, to find new biomarkers, to test new drugs or, fatally, to find new pathways applicable in future therapeutic approaches.
Keywords
Circadian Rhythm, Exosomes, Humans, Mesenchymal Stem Cells, Models, Biological, Parkinson Disease, Precision Medicine, Radicular Cyst, Parkinson's Disease, circadian rhythm, exosomes
Pubmed
Web of science
Open Access
Yes
Create date
01/04/2020 18:27
Last modification date
08/08/2024 6:42