Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis.
Journal of Neurology
Publication types: Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Progressive multifocal leucoencephalopathy (PML), a demyelinating disease caused by the JC virus (JCV), occurs in immunosuppressed patients and carries a poor prognosis. A favourable outcome is reported in two patients with PML and dermatomyositis. Immunosuppressive drugs were stopped in patient 1 but could only be partially tapered in patient 2. The JCV-specific CD8+ T cell response was strong in patient 1 and weak in patient 2. Both were treated with cytosine-arabinoside, and patient 2 was also treated with mirtazapine, a 5HT2A receptor antagonist. Combination of these drugs might be helpful to treat HIV-negative patients with PML.
Adrenergic alpha-Antagonists/therapeutic use, Cytarabine/therapeutic use, Dermatomyositis/complications, Female, Humans, Immunosuppressive Agents/therapeutic use, Leukoencephalopathy, Progressive Multifocal/drug therapy, Leukoencephalopathy, Progressive Multifocal/etiology, Male, Mianserin/analogs & derivatives, Mianserin/therapeutic use, Middle Aged, Treatment Outcome
Web of science
Last modification date