The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins.

Détails

ID Serval
serval:BIB_F9DA82EBAC80
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins.
Périodique
Biomaterials
Auteur(s)
Longchamp A., Alonso F., Dubuis C., Allagnat F., Berard X., Meda P., Saucy F., Corpataux J.M., Déglise S., Haefliger J.A.
ISSN
1878-5905 (Electronic)
ISSN-L
0142-9612
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
35
Numéro
9
Pages
2588-2599
Langue
anglais
Notes
Publication types: Journal Article
Résumé
The saphenous vein is the conduit of choice in bypass graft procedures. Haemodynamic factors play a major role in the development of intimal hyperplasia (IH), and subsequent bypass failure. To evaluate the potential protective effect of external reinforcement on such a failure, we developed an ex vivo model for the perfusion of segments of human saphenous veins under arterial shear stress. In veins submitted to pulsatile high pressure (mean pressure at 100 mmHg) for 3 or 7 days, the use of an external macroporous polyester mesh 1) prevented the dilatation of the vessel, 2) decreased the development of IH, 3) reduced the apoptosis of smooth muscle cells, and the subsequent fibrosis of the media layer, 4) prevented the remodelling of extracellular matrix through the up-regulation of matrix metalloproteinases (MMP-2, MMP-9) and plasminogen activator type I. The data show that, in an experimental ex vivo setting, an external scaffold decreases IH and maintains the integrity of veins exposed to arterial pressure, via increase in shear stress and decrease wall tension, that likely contribute to trigger selective molecular and cellular changes.
Pubmed
Web of science
Création de la notice
06/04/2014 16:36
Dernière modification de la notice
03/03/2018 22:54
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