Article: article from journal or magazin.
[Percutaneous radiofrequency ablation of hepatic metastases. Preliminary experience]
Gastroenterol Clin Biol
0399-8320 (Print)0399-8320 (Linking)
De Baere, TElias, DDucreux, MDromain, CKuach, VGamal El Din, MSobotka, ALasser, PRoche, AfreEnglish AbstractFRANCE2000/01/29Gastroenterol Clin Biol. 1999 Nov;23(11):1128-33.
AIM: To evaluate the efficiency of percutaneous radiofrequency ablation in the treatment of liver metastases. METHODS: Eighteen patients with 31 liver metastases, mainly from colorectal cancer, 10 - 35 mm in diameter (m = 23), underwent 26 courses of percutaneous radiofrequency ablation. Fifteen patients had previously undergone hepatectomy, and 3 patients had contra-indications to surgery. Imaging guidance was ultrasound in 21 patients, CT in 4 (tumors not seen with ultrasound), and both in 1. A generator working at 450 KHz with a maximum output power of 150 W was used to treat each lesion for 18 - 20 min. Treatment was monitored with real time ultrasound. RESULTS: Among the 12 patients followed more than 3 months, only one of the 24 treated lesions recurred after a mean follow up of 259 inverted question mark 109 days. Liver disease was controlled in 8 of the 12 patients after 90 - 509 days (m = 306). Among these 8 patients, 3 were tumor free after 559, 378 and 90 days, respectively; 2 died tumor free of non-tumoral disease (pulmonary embolism, digestive bleeding); 3 developed lung metastases treated with chemotherapy (n = 2) or surgery (n = 1). Three of the 12 patients had widespread hepatic tumor occurrence, and one patient died of these metastases. Six patients experienced mild skin burns, but no major complication was observed. CONCLUSION: Radiofrequency ablation of hepatic metastases appears safe and promising in this preliminary experience. Further investigation is needed.
Adult, Aged, Aged, 80 and over, *Catheter Ablation, Female, Humans, Liver Neoplasms/*secondary/*surgery, Male, Middle Aged, Retrospective Studies
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