Regulation of Stem Cell Aging by Metabolism and Epigenetics.

Détails

ID Serval
serval:BIB_F97C89F3FE2A
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Regulation of Stem Cell Aging by Metabolism and Epigenetics.
Périodique
Cell metabolism
Auteur(s)
Ren R., Ocampo A., Liu G.H., Izpisua Belmonte J.C.
ISSN
1932-7420 (Electronic)
ISSN-L
1550-4131
Statut éditorial
Publié
Date de publication
05/09/2017
Peer-reviewed
Oui
Volume
26
Numéro
3
Pages
460-474
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-associated declines in stem cell function are characterized by metabolic and epigenetic changes. Understanding the mechanisms underlying these changes will likely reveal novel therapeutic targets for ameliorating age-associated phenotypes and for prolonging human healthspan. Recent studies have shown that metabolism plays an important role in regulating epigenetic modifications and that this regulation dramatically affects the aging process. This review focuses on current knowledge regarding the mechanisms of stem cell aging, and the links between cellular metabolism and epigenetic regulation. In addition, we discuss how these interactions sense and respond to environmental stress in order to maintain stem cell homeostasis, and how environmental stimuli regulate stem cell function. Additionally, we highlight recent advances in the development of therapeutic strategies to rejuvenate dysfunctional aged stem cells.
Mots-clé
Animals, Cellular Senescence/genetics, Epigenesis, Genetic, Humans, Metabolome/genetics, Models, Biological, Stem Cells/metabolism, aging, epigenetics, metabolism, rejuvenation, stem cell aging
Pubmed
Web of science
Création de la notice
14/08/2018 10:25
Dernière modification de la notice
23/08/2018 6:26
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