Altered processing of contextual information during fear extinction in PTSD: an fMRI study.

Détails

ID Serval
serval:BIB_F94821D511AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Altered processing of contextual information during fear extinction in PTSD: an fMRI study.
Périodique
CNS Neuroscience and Therapeutics
Auteur(s)
Rougemont-Bücking A., Linnman C., Zeffiro T.A., Zeidan M.A., Lebron-Milad K., Rodriguez-Romaguera J., Rauch S.L., Pitman R.K., Milad M.R.
ISSN
1755-5949 (Electronic)
ISSN-L
1755-5930
Statut éditorial
Publié
Date de publication
2011
Volume
17
Numéro
4
Pages
227-236
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Medial prefrontal cortical areas have been hypothesized to underlie altered contextual processing in posttraumatic stress disorder (PTSD). We investigated brain signaling of contextual information in this disorder. Eighteen PTSD subjects and 16 healthy trauma-exposed subjects underwent a two-day fear conditioning and extinction paradigm. On day 1, within visual context A, a conditioned stimulus (CS) was followed 60% of the time by an electric shock (conditioning). The conditioned response was then extinguished (extinction learning) in context B. On day 2, recall of the extinction memory was tested in context B. Skin conductance response (SCR) and functional magnetic resonance imaging (fMRI) data were collected during context presentations. There were no SCR group differences in any context presentation. Concerning fMRI data, during late conditioning, when context A signaled danger, PTSD subjects showed dorsal anterior cingulate cortical (dACC) hyperactivation. During early extinction, when context B had not yet fully acquired signal value for safety, PTSD subjects still showed dACC hyperactivation. During late extinction, when context B had come to signal safety, they showed ventromedial prefrontal cortex (vmPFC) hypoactivation. During early extinction recall, when context B signaled safety, they showed both vmPFC hypoactivation and dACC hyperactivation. These findings suggest that PTSD subjects show alterations in the processing of contextual information related to danger and safety. This impairment is manifest even prior to a physiologically-measured, cue-elicited fear response, and characterized by hypoactivation in vmPFC and hyperactivation in dACC.
Mots-clé
Adaptation, Psychological, Adolescent, Adult, Association Learning/physiology, Brain Mapping, Case-Control Studies, Conditioning, Classical/physiology, Extinction, Psychological/physiology, Fear/physiology, Fear/psychology, Female, Humans, Magnetic Resonance Imaging, Male, Mental Recall/physiology, Prefrontal Cortex/physiology, Prefrontal Cortex/physiopathology, Reference Values, Stress Disorders, Post-Traumatic/physiopathology, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/01/2012 20:48
Dernière modification de la notice
09/05/2019 3:44
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