Biological variation of established and novel biomarkers for atherosclerosis: Results from a prospective, parallel-group cohort study.

Détails

ID Serval
serval:BIB_F933D8A8BCF9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Biological variation of established and novel biomarkers for atherosclerosis: Results from a prospective, parallel-group cohort study.
Périodique
Clinica Chimica Acta
Auteur(s)
Engelberger R.P., Limacher A., Kucher N., Baumann F., Silbernagel G., Benghozi R., Do D.D., Willenberg T., Baumgartner I.
ISSN
1873-3492 (Electronic)
ISSN-L
0009-8981
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
447
Pages
16-22
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND: Biomarkers are a promising tool for the management of patients with atherosclerosis, but their variation is largely unknown. We assessed within-subject and between-subject biological variation of biomarkers in peripheral artery disease (PAD) patients and healthy controls, and defined which biomarkers have a favorable variation profile for future studies.
METHODS: Prospective, parallel-group cohort study, including 62 patients with stable PAD (79% men, 65±7years) and 18 healthy control subjects (44% men, 57±7years). Blood samples were taken at baseline, and after 3-, 6-, and 12-months. We calculated within-subject (CVI) and between-subject (CVG) coefficients of variation and intra-class correlation coefficient (ICC).
RESULTS: Mean levels of D-dimer, hs-CRP, IL-6, IL-8, MMP-9, MMP-3, S100A8/A9, PAI-1, sICAM-1, and sP-selectin levels were higher in PAD patients than in healthy controls (P≤.05 for all). CVI and CVG of the different biomarkers varied considerably in both groups. An ICC≥0.5 (indicating moderate-to-good reliability) was found for hs-CRP, D-Dimer, E-selectin, IL-10, MCP-1, MMP-3, oxLDL, sICAM-1 and sP-selectin in both groups, for sVCAM in healthy controls and for MMP-9, PAI-1 and sCD40L in PAD patients.
CONCLUSIONS: Single biomarker measurements are of limited utility due to large within-subject variation, both in PAD patients and healthy subjects. D-dimer, hs-CRP, MMP-9, MMP-3, PAI-1, sP-selectin and sICAM-1 are biomarkers with both higher mean levels in PAD patients and a favorable variation profile making them most suitable for future studies.
Pubmed
Web of science
Création de la notice
24/08/2015 17:39
Dernière modification de la notice
03/03/2018 22:53
Données d'usage