Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase

Détails

ID Serval
serval:BIB_F91C704ED314
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase
Périodique
Journal of Clinical Investigation
Auteur(s)
Tissot  J. D., Schneider  P., Hauert  J., Ruegg  M., Kruithof  E. K., Bachmann  F.
ISSN
0021-9738 (Print)
Statut éditorial
Publié
Date de publication
12/1982
Volume
70
Numéro
6
Pages
1320-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
Two different plasmatic plasminogen activators (PA) can be demonstrated after sodium dodecyl sulfate polyacrylamide gel electrophoresis of plasma freshly collected from resting volunteers, followed by transfer of the gels onto plasminogen-rich fibrin-agarose plates. These two PA are also present in plasmas deficient in coagulation Factor XI, Factor XII, prekallikrein, or high molecular weight-kininogen. The slower-moving PA has an apparent 85,000 Mr and is immunologically unrelated to urokinase (UK). The faster moving PA was isolated by immunoadsorption of plasma on anti-UK IgG coupled to Sepharose 4B and appears to be identical to urinary high molecular weight-UK.
Mots-clé
Endopeptidases/*blood Humans Molecular Weight Plasminogen Activators/*blood Urinary Plasminogen Activator/*blood
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:34
Dernière modification de la notice
09/05/2019 3:43
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