Guiding ligands to nuclear receptors.
Details
Serval ID
serval:BIB_F90FCBBDF059
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
Guiding ligands to nuclear receptors.
Journal
Cell
ISSN
0092-8674 (Print)
ISSN-L
0092-8674
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
129
Number
4
Pages
649-651
Language
english
Abstract
Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid transporters-commits the cell to opposite fates, apoptosis or survival, respectively.
Keywords
Active Transport, Cell Nucleus/physiology, Animals, Apoptosis/physiology, Cell Nucleus/metabolism, Cell Survival/physiology, Humans, Ligands, PPAR-beta/metabolism, Receptors, Retinoic Acid/metabolism, Signal Transduction/physiology, Tretinoin/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:44
Last modification date
20/08/2019 17:24
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