Complete radiological response of colorectal liver metastases after chemotherapy: what can we expect?

Details

Serval ID
serval:BIB_F909C8E9186C
Type
Article: article from journal or magazin.
Collection
Publications
Title
Complete radiological response of colorectal liver metastases after chemotherapy: what can we expect?
Journal
Dig Surg
Author(s)
Gaujoux S., Goere D., Dumont F., Souadka A., Dromain C., Ducreux M., Elias D.
ISSN-L
1421-9883 (Electronic)0253-4886 (Linking)
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
28
Number
2
Pages
114-20
Language
english
Notes
Gaujoux, SebastienGoere, DianeDumont, FredericSouadka, AmineDromain, ClarisseDucreux, MichelElias, DominiqueengResearch Support, Non-U.S. Gov'tSwitzerland2011/05/05 06:00Dig Surg. 2011;28(2):114-20. doi: 10.1159/000323819. Epub 2011 Apr 29.
Abstract
Missing metastases, also called vanishing or disappearing liver metastases, concern about 5% of patients with colorectal liver metastasis undergoing chemotherapy, and this phenomenon is likely to become more frequent in the near future, with the widespread use of highly efficient chemotherapy. As their definition is highly dependent on the quality of initial imaging, a DLM on preoperative computed tomography scan should be systematically confirmed by a second imaging modality, ideally magnetic resonance imaging. It is important to note that a complete clinical response does not mean a complete pathologic response. Currently, there are no absolute criteria of a complete pathologic response. However, treatment with neoadjuvant and adjuvant hepatic arterial infusion in patients <60 years old with an initially low carcinoembryonic antigen level that normalizes under chemotherapy and who have no detectable lesion on both computed tomography and magnetic resonance imaging is probably more likely to yield a complete pathologic response. Whatever their treatment, patients with DLM run a high risk of recurrence that could be decreased with the use of HAI. Despite a high recurrence rate, the overall 5-year survival rate of patients with DLM ranges from 40 to 80%. Having a DLM should no longer be a contraindication to hepatic surgery since long-term survival is expected in these highly chemosensitive patients. The use of adjuvant HAI in addition to efficient systemic chemotherapy could reduce the risk of hepatic relapse.
Keywords
Chemotherapy, Adjuvant, Colorectal Neoplasms/*pathology, Hepatectomy, Humans, Liver Neoplasms/*drug therapy/pathology/*radiography/secondary/surgery, Magnetic Resonance Imaging, *Neoadjuvant Therapy, Positron-Emission Tomography, Remission Induction, Tomography, X-Ray Computed, Treatment Outcome
Create date
16/09/2016 10:14
Last modification date
20/08/2019 16:24
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