Human cytomegalovirus induced pseudotumor of upper gastrointestinal tract mucosa: Effects of long-term chronic disease?

Détails

ID Serval
serval:BIB_F8F8CB872BF3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Human cytomegalovirus induced pseudotumor of upper gastrointestinal tract mucosa: Effects of long-term chronic disease?
Périodique
Journal of Medical Virology
Auteur(s)
Reggiani Bonetti L., Barresi V., Bertani A., Maccio L., Palmiere C.
ISSN
1096-9071 (Electronic)
ISSN-L
0146-6615
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
87
Numéro
6
Pages
1041-1045
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Human cytomegalovirus-induced lesions resembling malignancies have been described in the gastrointestinal tract and include ulcerated or exophytic large masses. The aim of this study was to review the cases registered in the databases of two academic hospitals and formulate a hypothesis concerning the pathogenic mechanisms responsible for cytomegalovirus-induced pseudotumor development. All the diagnoses of human cytomegalovirus infections of the upper gastrointestinal tract recorded from 1991 to 2013 were reviewed. Cases of mucosal alterations misdiagnosed endoscopically as malignancies were selected. Large ulcers occurring in the stomach (three cases) and an irregular exophytic mass at the gastro-jejunal anastomosis were misdiagnosed endoscopically as malignancies (4 cases out of 53). Histologically, all lesions reflected hyperplastic mucosal changes with a prevalence of epithelial and stroma infected cells, without signs of cell atypia. The hypothesis presented is that the development of human cytomegalovirus-induced pseudotumors may be the morphological expression of chronic mucosa damage underlying long-term infection.
Pubmed
Web of science
Création de la notice
11/05/2015 13:17
Dernière modification de la notice
03/03/2018 22:53
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