Inflammation in gout: mechanisms and therapeutic targets.

Détails

ID Serval
serval:BIB_F8C4ACBA5649
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Inflammation in gout: mechanisms and therapeutic targets.
Périodique
Nature Reviews. Rheumatology
Auteur(s)
So A.K., Martinon F.
ISSN
1759-4804 (Electronic)
ISSN-L
1759-4790
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
13
Numéro
11
Pages
639-647
Langue
anglais
Résumé
The acute symptoms of gout are triggered by the inflammatory response to monosodium urate crystals, mediated principally by macrophages and neutrophils. Innate immune pathways are of key importance in the pathogenesis of gout, in particular the activation of the NLRP3 inflammasome, which leads to the release of IL-1β and other pro-inflammatory cytokines. The orchestration of this pro-inflammatory cascade involves multiple intracellular and extracellular receptors and enzymes interacting with environmental influences that modulate the inflammatory state. Furthermore, the resolution of inflammation in gout is becoming better understood. This Review highlights recent advances in our understanding of both positive and negative regulatory pathways, as well as the genetic and environmental factors that modulate the inflammatory response. Some of these pathways can be manipulated and present novel therapeutic opportunities for the treatment of acute gout attacks.

Mots-clé
Cytokines/metabolism, Gout/immunology, Gout/metabolism, Gout/therapy, Humans, Immunity, Innate, Immunosuppression/methods, Inflammasomes/metabolism, Inflammation/immunology, Inflammation/metabolism, Macrophages/immunology, Macrophages/metabolism, Neutrophils/immunology, Neutrophils/metabolism
Pubmed
Web of science
Création de la notice
12/10/2017 9:56
Dernière modification de la notice
03/03/2018 22:52
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