Evidence that recurrent Plasmodium falciparum infection is caused by recrudescence of resistant parasites
Details
Serval ID
serval:BIB_F8A29B3E84CD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Evidence that recurrent Plasmodium falciparum infection is caused by recrudescence of resistant parasites
Journal
American Journal of Tropical Medicine and Hygiène
ISSN
0002-9637 (Print)
Publication state
Published
Issued date
04/1997
Volume
56
Number
4
Pages
436-9
Notes
Journal Article --- Old month value: Apr
Abstract
Isolates of Plasmodium falciparum obtained from 12 children attending different health facilities in the Madang Province, Papua New Guinea were typed for allelic variants of merozoite surface protein-1 and merozoite surface protein-2. Blood was obtained just before treatment with either amodiaquine or chloroquine and at intervals following treatment. All patients examined were found to be infected with genetically different parasites. Nine of the children were found to have single infections while three had mixed infections. In all patients, parasites reappearing in the blood following treatment had the same genotype as parasites in the primary infection. These results indicate that parasites reappearing in the blood following treatment were the result of true recrudescence and not new infections.
Keywords
Alleles
Animals
*Antigens, Protozoan
Child
Child, Preschool
Drug Resistance/genetics
Female
Gene Frequency
Genotype
Humans
Malaria, Falciparum/*parasitology
Male
Merozoite Surface Protein 1
Plasmodium falciparum/classification/*drug effects/genetics
Protein Precursors/genetics
Protozoan Proteins/genetics
Recurrence
Variation (Genetics)
Pubmed
Web of science
Create date
28/01/2008 12:49
Last modification date
20/08/2019 17:24