Quantitative multiparameter assays to measure the effect of adjuvants on human antigen-specific CD8 T-cell responses.

Détails

Ressource 1Télécharger: BIB_F8A15042C403.P001.pdf (2096.07 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_F8A15042C403
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Quantitative multiparameter assays to measure the effect of adjuvants on human antigen-specific CD8 T-cell responses.
Périodique
Methods in Molecular Biology
Auteur(s)
Derré L., Jandus C., Baumgaertner P., Posevitz V., Devêvre E., Romero P., Speiser D.E.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2010
Volume
626
Pages
231-249
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Large numbers and functionally competent T cells are required to protect from diseases for which antibody-based vaccines have consistently failed (1), which is the case for many chronic viral infections and solid tumors. Therefore, therapeutic vaccines aim at the induction of strong antigen-specific T-cell responses. Novel adjuvants have considerably improved the capacity of synthetic vaccines to activate T cells, but more research is necessary to identify optimal compositions of potent vaccine formulations. Consequently, there is a great need to develop accurate methods for the efficient identification of antigen-specific T cells and the assessment of their functional characteristics directly ex vivo. In this regard, hundreds of clinical vaccination trials have been implemented during the last 15 years, and monitoring techniques become more and more standardized.
Mots-clé
Adjuvants, Immunologic/pharmacology, CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/drug effects, Cell Proliferation, Cells, Cultured, Drug Evaluation, Preclinical/methods, Humans, Lymphocyte Activation/drug effects
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/02/2011 15:24
Dernière modification de la notice
09/05/2019 3:42
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