G-CSF-induced remission in two cases of acute myeloid leukemia.

Details

Serval ID
serval:BIB_F893A9016004
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
G-CSF-induced remission in two cases of acute myeloid leukemia.
Journal
Leukemia Research
Author(s)
Benz R., Goede J.S., Parlier V., Mühlematter D., Jotterand M., Fehr J.
ISSN
0145-2126
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
32
Number
7
Pages
1148-1152
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
We report on two elderly patients with newly diagnosed acute myeloid leukemia (AML) who were treated in palliative intention because of comorbidities and intermediate or poor risk cytogenetics. Both received G-CSF to reduce the risk of infection related to neutropenia. Interestingly, one patient achieved a full hematological remission and the other a peripheral remission with dramatic reduction of the bone marrow blast count. Although a direct therapeutic effect of myeloid growth factors seems to be unusual in AML, the use of G-CSF or GM-CSF may be recommended in patients such as elderly patients who are not suited for intensive chemotherapy.
Keywords
Aged, Female, Granulocyte Colony-Stimulating Factor/therapeutic use, Humans, Leukemia, Myeloid, Acute/drug therapy, Male, Middle Aged, Remission Induction
Pubmed
Web of science
Create date
29/09/2009 15:47
Last modification date
20/08/2019 16:24
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