Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
G-CSF-induced remission in two cases of acute myeloid leukemia.
Publication types: Case Reports ; Journal Article
We report on two elderly patients with newly diagnosed acute myeloid leukemia (AML) who were treated in palliative intention because of comorbidities and intermediate or poor risk cytogenetics. Both received G-CSF to reduce the risk of infection related to neutropenia. Interestingly, one patient achieved a full hematological remission and the other a peripheral remission with dramatic reduction of the bone marrow blast count. Although a direct therapeutic effect of myeloid growth factors seems to be unusual in AML, the use of G-CSF or GM-CSF may be recommended in patients such as elderly patients who are not suited for intensive chemotherapy.
Aged, Female, Granulocyte Colony-Stimulating Factor/therapeutic use, Humans, Leukemia, Myeloid, Acute/drug therapy, Male, Middle Aged, Remission Induction
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