G-CSF-induced remission in two cases of acute myeloid leukemia.

Détails

ID Serval
serval:BIB_F893A9016004
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
G-CSF-induced remission in two cases of acute myeloid leukemia.
Périodique
Leukemia Research
Auteur(s)
Benz R., Goede J.S., Parlier V., Mühlematter D., Jotterand M., Fehr J.
ISSN
0145-2126
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
32
Numéro
7
Pages
1148-1152
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
We report on two elderly patients with newly diagnosed acute myeloid leukemia (AML) who were treated in palliative intention because of comorbidities and intermediate or poor risk cytogenetics. Both received G-CSF to reduce the risk of infection related to neutropenia. Interestingly, one patient achieved a full hematological remission and the other a peripheral remission with dramatic reduction of the bone marrow blast count. Although a direct therapeutic effect of myeloid growth factors seems to be unusual in AML, the use of G-CSF or GM-CSF may be recommended in patients such as elderly patients who are not suited for intensive chemotherapy.
Mots-clé
Aged, Female, Granulocyte Colony-Stimulating Factor/therapeutic use, Humans, Leukemia, Myeloid, Acute/drug therapy, Male, Middle Aged, Remission Induction
Pubmed
Web of science
Création de la notice
29/09/2009 16:47
Dernière modification de la notice
03/03/2018 22:52
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